Peptide ligands which bind to von willebrand factor

Details Peptide ligands which bind to von willebrand factor Peptide ligands which bind to von willebrand factor

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) C07K 1/22 (2006.01) C07K 14/00 (2006.01) C07K 14/725 (2006.01) C07K 14/745 (2006.01)

Patent

CA 2185856

Peptide ligands which bind to von Willebrand Factor (vWF) are disclosed. These peptides are selected from the group consisting of RLHSFY, RLKSFY, RLNSFY, RLQSFY, RFRSFY, RIRSFY, RVRSFY, RYRSFY, RLRSFY, HLRSFY, and KLRSFY. The preferred peptide ligand has the sequence RVRSFY. A method of using the disclosed peptides to purify vWF comprises binding the peptides to a support, then passing a solution containing vWF over the supports under conditions such that the vWF will selectively bind to the peptides, and then eluting the vWF.

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