Peptide-lipid conjugates, liposomes and liposomal drug delivery

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/10 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2276267

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.

On incorpore des conjugués de peptide-lipide dans des liposomes de manière à déstabiliser sélectivement les liposomes au voisinage de cellules cibles sécrétant de la peptidase et apporter ainsi les liposomes au voisinage de cellules cibles ou bien directement dans lesdites cellules. On peut par conséquent utiliser les liposomes pour traiter chez des mammifères des maladies, des dérèglements ou des états pahtologiques tels que des tumeurs, des infections microbiennes et des inflammations caractérisées par la présence de cellules sécrétant de la peptidase.

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