Peptide-lipid conjugates, liposomes and liposomal drug delivery

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 9/127 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2376859

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.

Cette invention se rapporte à des conjugués peptides-lipides qui sont incorporés dans des liposomes, afin de déstabiliser sélectivement les liposomes à proximité de cellules cibles sécrétant de la peptidase et, ainsi, acheminer les liposomes à proximité des cellules cibles ou directement dans lesdites cellules. Les liposomes peuvent par conséquent être utilisés pour traiter des mammifères souffrant de maladies, troubles ou états, tels que tumeurs, infections microbiennes et inflammations, se caractérisant par la présence de cellules sécrétant de la peptidase.

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