Peptide, process for preparation thereof and use thereof

Details Peptide, process for preparation thereof and use thereof Peptide, process for preparation thereof and use thereof

C - Chemistry, Metallurgy

07

K

530/5

C07K 5/04 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1247083

ABSTRACT OF THE DISCLOSURE Peptides of the formula Image wherein R1 is hydrogen or acyl, R2 is hydrogen or lower alkyl, R3 and R6 are each carboxy, protected carboxy, carbamoyl or hydroxymethyl, R4 is hydrogen, lower alkyl or hydroxy(lower)- alkyl, R5 is hydrogen, carboxy, protected carboxy, carbamoyl, carboxy or protected carboxy(lower)alkyl, or hydroxy(lower)- alkyl, R7 is hydrogen or an amino protective group, and n is an integer 0 or 1, with proviso that in the restricted case that each of R3 and R6 is not simultaneously hydroxy- methyl, R4 or R5 should be always hydroxy(lower)alkyl, and their pharmaceutically acceptable salts can be used in the therapeutic treatment of infectious diseases caused by pathogenic microorganisms, especially gram-negative bacteria and gram-positive bacteria and fungi.

391225

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