Peptides and compounds that bind to the il-1 receptor

Details Peptides and compounds that bind to the il-1 receptor Peptides and compounds that bind to the il-1 receptor

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) C07K 7/00 (2006.01) C07K 14/545 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2222939

Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of: (1) WXXXGZ1W; (2) XXQZ5YZ6XX and (3) Z23NZ24SZ25Z26Z27Z28Z29Z30L. Also provided are peptides which bind to the IL-1RtI, which are 11 to 40 amino acids in length, which comprise the core sequence of amino acids Z31XZ41Z32Z34Z36Z42Z37Z38.

L'invention concerne des peptides se fixant sur le récepteur de type I de l'interleukine-1 (IL-1¿RtI?) et pouvant être utilisés pour doser la quantité d'IL-1R, ou bien d'un agoniste ou d'un antagoniste d'IL-1R, dans un échantillon. Ces peptides comprennent une séquence d'aminoacides choisis dans le groupe composé de: (1) WXXXGZ1W; (2) XXQZ¿5?YZ¿6?XX et (3) Z¿23?NZ¿24?SZ¿25?Z¿26?Z¿27?Z¿28?Z¿29?Z¿30?L. Sont également décrits des peptides qui se fixent sur l'IL-1¿RtI?, sont d'une longueur de 11 à 40 aminoacides et comprennent la séquence fondamentale d'aminoacides Z¿31?XZ¿41?Z¿32?Z¿34?Z¿36?Z¿42?Z¿37?Z¿38?.

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