Peptides having renin inhibitory activity their preparation...

Details Peptides having renin inhibitory activity their preparation... Peptides having renin inhibitory activity their preparation...

C - Chemistry, Metallurgy

07

D

167/208, 260/302

C07D 277/30 (2006.01) A61K 31/425 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2010260

ABSTRACT Compounds of formula (I): Image (I) [in which: R1 is heterocyclic group having 5 or 6 ring atoms, or -NR7R8, where R7 is alkyl and R8 is optionally substituted phenyl, optionally substituted phenylalkyl or cycloalkyl; R2 is optionally substituted phenyl or naphthyl; R3 is thiazolyl; R4 is cyclohexyl or isopropyl; R5 is alkyl; and R6 is alkyl] and salts thereof have renin-inhibitory and, hence, hypotensive activities and are of value in the diagnosis and treatment of hypertension induced by failures in the renin-angiotensin system. They may be prepared by reacting together appropriate amino acids or derivatives thereof.

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