Peptidyl derivatives

Details Peptidyl derivatives Peptidyl derivatives

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) C07C 55/02 (2006.01) C07C 237/22 (2006.01) C07C 311/46 (2006.01) C07C 323/60 (2006.01) C07D 207/00 (2006.01) C07D 209/20 (2006.01) C07D 209/26 (2006.01) C07K 5/06 (2006.01) C07K 5/072 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2073510

2073510 9209564 PCTABS00013 Compounds of formula (I) are described wherein R represents a -CONHOH, carboxyl (-CO2H) or esterified carboxyl group; R1 represents an optionally substituted alkyl, alkenyl, aryl, aralkyl, heteroaralkyl or heteroarylthioalkyl group; R2 represents an optionally substituted phenylethyl, phenylpropyl or phenylbutyl group; R3 represents a hydrogen atom or an alkyl group; R4 represents a hydrogen atom or an alkyl group; R5 represents an optionally substituted alkyl or alkenyl group optionally interrupted by one or more -O- or -S- atoms or -N(R7)-groups [where R7 is a hydrogen atom or a C1-6alkyl group]; X represents an amino (-NH2), or substituted amino, hydroxyl or substituted hydroxyl group; and the salts, solvates and hydrates thereof. The compounds are metalloproteinase inhibitors and in particular have a selective gelatinase action, and may be of use in the treatment of cancer to control the development of tumour metastases.

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