Peptidyl derivatives as inhibitors of interleukin-1.beta....

Details Peptidyl derivatives as inhibitors of interleukin-1.beta.... Peptidyl derivatives as inhibitors of interleukin-1.beta....

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) A61K 31/195 (2006.01) A61K 38/04 (2006.01) C07C 229/22 (2006.01) C07C 229/34 (2006.01) C07C 233/47 (2006.01) C07C 233/51 (2006.01) C07K 5/02 (2006.01)

Patent

CA 2071674

Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune- based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardio- vascular system including the pericardium; the gastro- intestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e. g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. (See formula I)

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