C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/428 (2006.01) A61K 38/05 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 277/64 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01)
Patent
CA 2361479
The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particularly, these compounds are potent and selective inhibitors of tryptase and are therefore effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.
L'invention porte sur une série de peptidylcétones hétérocycliques inhibiteurs de la sérine protéase des cellules inflammatoires, sur leur composition, et sur des procédés de prévention et traitement de différents troubles de nature inflammatoire liés à l'immunité. Ces compositions sont plus particulièrement des inhibiteurs puisant et sélectifs de la tryptase et de ce fait efficaces pour la prévention et le traitement de maladies inflammatoires associées aux voies respiratoires telles que l'asthme et la rhinite allergique.
Costanzo Michael J.
Maryanoff Bruce E.
Yabut Stephen C.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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