A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2630704
A chemically stable formulation of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrim idin-5-yl]-(3R, 5S)-3,5-dihydroxyhept-6- enoic acid or a pharmaceutically-acceptable salt thereof for oral use, such as tablets, capsules, powders, granules has been developed using the substances which stabilize against formation of degradation products: lactone and oxidation product.
La présente invention concerne une formulation chimiquement stable d'acide (E)-7-[4-(4-fluorophényl)-6-isopropyl-2- [méthyl(méthylsul-fonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-énoïque ou d'un sel pharmaceutiquement acceptable de celui-ci pour utilisation orale, telle que des comprimés, des capsules, des poudres, des granules, développée en utilisant les substances qui stabilisent contre la formation de produits de dégradation tels que lactone et produit d'oxydation.
Jaklic Miha Tomaz
Naversnik Klemen
Goudreau Gage Dubuc
Lek Pharmaceuticals D.d.
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