A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/277 (2006.01) A61K 9/20 (2006.01) A61K 31/12 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2342634
The present invention relates to an oral compacted composition comprising entacapone, nitecapone, or a pharmaceutically acceptable salt thereof and a cross-linked cellulose derivative. The composition is premised on the discovery that the cross-linked cellulose derivative increases the release rate of entacapone or nitecapone from an oral compacted composition. Preferably the amount of the cross-linked cellulose derivative in the composition is at least 6 % by weight, preferably from about 8 % to about 16 % weight, especially from about % to about 14 % by weight.
L'invention concerne une composition orale comprimée, comprenant une entacapone, une nitécapone, ou un sel de celles-ci, acceptable sur le plan pharmacologique, ainsi qu'un dérivé de cellulose réticulé. Cette composition est caractérisée par la découverte que le dérivé de cellulose réticulé augmente le taux de libération de l'entacapone ou de la nitécapone, à partir d'une composition orale comprimée. De préférence, la dose du dérivé de cellulose réticulé présent dans la composition est d'au moins 6 % en poids, de préférence de 8 à 16 %, environ, et idéalement de 10 à 14 %, environ, en poids.
Orion Corporation
Robic
LandOfFree
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