Pharmaceutical compositions containing lysostaphin alone or...

Details Pharmaceutical compositions containing lysostaphin alone or... Pharmaceutical compositions containing lysostaphin alone or...

A - Human Necessities

61

K

A61K 38/46 (2006.01) A61K 31/395 (2006.01) A61K 38/08 (2006.01) A61K 38/48 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2297083

Lysostaphin is demonstrated to be a powerful anti-staphylococcal agent suitable for parental administration to mammals including humans. Low dosages, on the order of 0.5 - 45 mg/kg/day are sufficient to eradicate most staphylococcal infections. Lysostaphin is also effective against bacteria of this type which have developed resistance to conventional antibiotics such as penicillins and vancomycin. Lysostaphin analogues, such as variants and related enzymes, show similar activity.

La lysostaphine est connue pour être un agent antistaphylococcique puissant qui se prête à l'administration parentérale aux mammifères, y compris aux êtres humains. Les faibles dosages, de l'ordre de 0,5-45 mg/kg/jour sont suffisants pour venir à bout de la plupart des infections staphylococciques. La lysostaphine est également efficace contre les bactéries du type considéré qui ont acquis une résistance aux antibiotiques classiques, comme les pénicillines et la vancomycine. Les analogues de la lysostaphine (par exemple, variantes et enzymes apparentées) démontrent une activité similaire.

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