C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2717792
The present invention provides compositions and methods of treatment of diseases that are sensitive to drugs that downregulate the function of microRNA's, mRNA, non-coding RNA, or viral genomes. In particular, it has been discovered that a very long term effect of an anti microRNA oligonucleotide may be obtained when administered to a primate. Therefore, the present invention relate to pharmaceutical compositions and methods for treatment of primates, including humans wherein the compositions are administered with a long time interval.
La présente invention concerne des compositions et des procédés de traitement de maladies qui sont sensibles à des médicaments qui régulent à la baisse la fonction de microARN, dARNm, dARN non codant, ou de génomes viraux. En particulier, il a été découvert quun effet à très long terme dun oligonucléotide anti-microARN peut être obtenu lorsquil est administré à un primate. Par conséquent, la présente invention concerne des compositions pharmaceutiques et des procédés de traitement de primates, comprenant des humains, caractérisées en ce que les compositions sont administrées à un intervalle très long.
Abrahamsen Niels
Hildebrandt-Eriksen Elisabeth
Kauppinen Sakari
Munk Martin
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Santaris Pharma A/s
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