C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2633766
The present invention relates to pharmaceutical compositions for the treatment of an epithelial tumor in a human, said pharmaceutical composition comprising a bispecific single chain antibody which has a first binding domain specifically binding to human CD3, and a second binding domain specifically binding to human CEA, wherein said second binding domain comprises at least a part of the CDR-H3 or the complete CDR-H3 of murine monoclonal antibody A5B7. Furthermore, processes for the production of said pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CEA antigen are disclosed.
La présente invention concerne des préparations pharmaceutiques pour le traitement d'une tumeur épithéliale chez un humain, ladite préparation pharmaceutique comprenant un anticorps à chaîne unique bi-spécifique présentant un premier domaine de liaison se liant spécifiquement au CD3 humain, et un second domaine de liaison se liant spécifiquement à l'ACE humain, ledit second domaine de liaison comprenant au moins une partie du CDR-H3 ou la totalité du CDR-H3 de l'anticorps monoclonal murin A5B7. En outre, la présente invention concerne des procédés de production desdites préparations pharmaceutiques, ainsi que des applications médicales/pharmaceutiques des molécules d'anticorps à chaîne unique bi-spécifiques portant des domaines spécifiques vis-à-vis de l'antigène CD3 humain et de l'antigène ACE humain.
Kufer Peter
Lutterbuse Ralf
Mangold Susanne
Mayer Petra
Murr Alexander
Goudreau Gage Dubuc
Micromet Ag
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