C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 475/08 (2006.01) A61K 31/505 (2006.01)
Patent
CA 2522538
The present invention relates to pharmaceutically active ornithine compounds, particularly to pharmaceutically acceptable ammonium salts of N.delta.-acyl derivatives of N.alpha.(4-amino-4-deoxypteroyl)-L-ornithine compounds; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such ammonium salts. The ammonium salts provided by the invention exhibit superior chemical stability than corresponding acidic N.delta.-acyl derivatives of N.alpha.(4-amino-4-deoxypteroyl)-L-ornithine compounds.
La présente invention concerne des composés d'ornithine pharmaceutiquement actifs, en particulier des sels d'ammonium pharmaceutiquement acceptables de dérivés N?.delta.¿-acyl de composés N?.alpha.¿(4-amino-4-désoxyptéroyl)-L-ornithine. L'invention concerne également des procédés de traitement et des compositions pharmaceutiques faisant intervenir ou contenant un ou plusieurs de ces sels d'ammonium. Les sels d'ammonium selon l'invention présentent une meilleure stabilité chimique que les dérivés N?.delta.¿-acyl acides correpondants de composés N?.alpha.¿(4-amino-4-désoxyptéroyl)-L-ornithine.
Bader Henry
Blumbergs Peter
Lin Ming-Teh
Rosowsky Andre
Ash Stevens Inc.
Dana-Farber Cancer Institute
Osler Hoskin & Harcourt Llp
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