Pharmacologically active tricyclic derivatives

Details Pharmacologically active tricyclic derivatives Pharmacologically active tricyclic derivatives

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2085705

ABSTRACT PHARMACOLOGICALLY ACTIVE TRICYCLIC DERIVATIVES The present invention refers to a new group of chemical substances of general formula I, and intermediates for the preparation thereof, which are uesful, among other uses, as psychotropic agents. It also refers to the processes used to obtain them. The new compounds of this invention include 5,10-dihydro-4,4-dioxothieno[3,2-c][2,1]- benzothiazepine; 5,10-dihydro-4,4-dioxothieno[3,2-c][2,1]- benzothiazepine; 4,9-dihydro-10,10-dioxothieno[2,3-c][2,1]- benzothiazepine; 4,9-dihydro-10,10-dioxo-2H-pyrazolo[3,4- c][2,1]benzothiazepine, 4,9-dihydro-10,10-dioxo-1H-pyrazo- lo[3,4-o][2,1]benzothiazepine and 4,9-dihydro-10,10- dioxothiazolo[5,4-c][2,1]benzothiazepine systems, which are new heterocyclic systems, described for the first time in the present invention. The derivatives of formula I are basic compounds, due to the presence of an aminio nitrogen and thay form stable salts with several acids. They are useful as antidepressant, diuretic, antihypertensive, antihistaminic, anticonvulsive, antipyretic, anti-inflamma- tory and/or analgesic agents. Image I

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