C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/21 (2006.01) A61K 31/192 (2006.01) A61P 17/00 (2006.01) A61P 37/08 (2006.01) C07C 311/29 (2006.01)
Patent
CA 2707789
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives of formula I wherein R1 is alkyl or cycloalkyl; R2 is halo, alky I, haloalkyl, alkoxy, haloalkoxy or cycloalkyl; and X is chloro or fluoro.
La présente invention concerne des composés, des compositions pharmaceutiques et des procédés utiles dans le traitement de maladies et d'états inflammatoires et du système immunitaire. En particulier, l'invention concerne des composés modulateurs de la fonction et/ou de l'expression de protéines impliquées dans des maladies atopiques, des états inflammatoires et le cancer. Les composés selon l'invention sont des dérivés de l'acide carboxylique de formule I dans laquelle R1 est alkyle ou cycloalkyle; R2 est halo, alkyle, haloalkyle, alcoxy, haloalcoxy ou cycloalkyle; et X est chloro ou fluoro.
Allgeier Alan
Grillo Mark
Jona Janan
Li An-Rong
Liu Jiwen
Amgen Inc.
Gowling Lafleur Henderson Llp
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