C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/05 (2006.01) A61K 31/16 (2006.01) A61K 31/255 (2006.01) A61K 31/275 (2006.01) C07C 233/65 (2006.01) C07C 255/50 (2006.01) C07C 305/18 (2006.01)
Patent
CA 2566053
The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
Cette invention concerne les composés de phényl carboximade qui sont des inhibiteurs de l~enzyme bêta sécrétase et sont utiles dans le traitement des maladies dans lesquelles l~enzyme bêta sécrétase joue un rôle, à l~instar de la maladie d~Alzheimer. Cette invention concerne également les préparations pharmaceutiques contenant ces composés et l~utilisation de ces composés et de ces préparations dans le traitement de maladies dans lesquelles l~enzyme bêta sécrétase joue un rôle.
Annis David Allen Jr.
Coburn Craig A.
Makara Gergely M.
Nash Huw M.
Steele Thomas G.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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