C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 215/42 (2006.01) A61K 31/135 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2688493
Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.
La présente invention concerne les dérivés de cyclohéxylamine substitués par un phényle ainsi que leur procédé de synthèse et leur caractérisation. L'utilisation de ces composés pour traiter/prévenir des désordres neurologiques ainsi que les procédés pour les synthétiser sont également évoqués ici. Des exemples de composés de l'invention inhibent la réabsorption de monoamines endogènes telles que la dopamine, la sérotonine et la norépinephrine (par ex. depuis la fente synaptique) et modulent un ou plusieurs transporteurs de monoamine. Les composés ayant la formulation pharmaceutique de la présente invention sont également présentés.
Campbell Una
Engel Sharon Rae
Hardy Larry Wendell
Hewitt Michael Charles
Koch Patrick
Gowling Lafleur Henderson Llp
Sepracor Inc.
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