Phenyloxazolidinones having a c-c bond to 4-8 membered...

Details Phenyloxazolidinones having a c-c bond to 4-8 membered... Phenyloxazolidinones having a c-c bond to 4-8 membered...

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 419/14 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2228647

A compound of formula (I), or pharmaceutical acceptable salts thereof wherein X is NR1, S(O)g, or O; R1 is H, C1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R1 is -(CH2)h-aryl, -COR1-1, -COOR1-2, -CO-(CH2)h- COR1-1, C1-6 alkyl sulfonyl,-SO2-(CH2)h-aryl, or -(CO)i-Het; R2 is H, C1-6 alkyl, -(CH2)h-aryl, or halo; R3 and R4 are the same or different and are H or halo; R5 is H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy. The compounds are useful antimicrobial agents.

L'invention porte sur un composé de formule (I) ou ses sels pharmacocompatibles, formule dans laquelle: X est NR¿1?,S(O)¿g?, ou O; R¿1? est H, C¿1-6? alkyle éventuellement substitué par un ou plusieurs OH, CN, ou halo, ou R¿1? est -(CH¿2?)¿h?-aryle, -COR¿1-1?, COOR¿1-2?, -CO-(CH¿2?)¿h?-COR¿1-1?, C¿1-6? alkyle sulfonyle, -SO¿2?-(CH¿2?)¿h?-aryle, ou -(CO)¿i?-Het; R¿2? est H, C¿1-6? alkyle, -(CH¿2?)¿h?-aryle ou halo, R¿3? et R¿4? sont identiques ou différents, et représentent H ou halo; R¿5? est H, C¿1-12? alkyle éventuellement substitué par un ou plusieurs halo, C¿3-12? cycloalkyle, C¿1-6? alcoxy. Ces composés sont d'utiles agents antimicrobiens.

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