Phl p 1 allergen derivative

Details Phl p 1 allergen derivative Phl p 1 allergen derivative

C - Chemistry, Metallurgy

07

K

C07K 14/415 (2006.01) A61K 39/36 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2649057

Method for producing derivatives of wild-type protein allergen Phl p 1 with reduced allergenic activity compared to the wild-type allergen, comprising the following steps: providing wild-type protein allergen Phl p 1, fragmenting said wild-type protein allergen into at least three fragments, wherein at least one fragment of said at least three fragments comprises at least one T-cell epitope and said at least three fragments have a reduced allergenic activity or lack allergenic activity and rejoining said at least three fragments in an order differing from the order of the fragments in the wild-type allergen.

L'invention concerne un procédé d'obtention de dérivés d'allergène protéique de type sauvage Phl p 1 présentant une activité allergénique réduite par rapport à l'allergène de type sauvage, le procédé comprenant les étapes suivantes : se procurer l'allergène protéique de type sauvage Phl p 1, le fragmenter en au moins trois fragments, au moins un fragment des au moins trois fragments comprenant au moins un épitope de lymphocyte T et ayant une activité allergénique réduite ou nulle; enfin, réunir les au moins trois fragments dans un ordre différent de l'ordre des fragments dans l'allergène de type sauvage.

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