C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/502 (2006.01) A61K 31/517 (2006.01) A61P 25/18 (2006.01) C07D 401/14 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2644280
The present invention if directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
La présente invention concerne certains composés de cinnoline qui sont des inhibiteurs de la PDE10, des compositions pharmaceutiques contenant ces composés et des procédés de préparation de ces composés. L'invention concerne également des procédés de traitement de maladies médiées par l'enzyme PDE10 telles que l'obésité, le diabète non insulinodépendant, la schizophrénie, le trouble bipolaire, le trouble obsessionnel compulsif et similaires.
Arrington Mark P.
Conticello Richard D.
Gauss Carla
Hess Hans-Jurgen
Hitchcock Stephen A.
Amgen Inc.
Memory Pharmaceuticals Corporation
Osler Hoskin & Harcourt Llp
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