Phosphoramidate derivatives of guanosine nucleoside...

Details Phosphoramidate derivatives of guanosine nucleoside... Phosphoramidate derivatives of guanosine nucleoside...

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) A61K 31/7052 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2749394

Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.

L'invention porte sur des composés de phosphoramidate issus de bases guanine ayant une puissance thérapeutique améliorée, et ces composés ont en particulier une puissance améliorée par rapport à un traitement d'infections virales, telles que le virus de l'hépatite C. L'invention porte également sur des compositions pharmaceutiques, des procédés de préparation des composés et des procédés d'utilisation des composés et sur les compositions pour traiter des infections virales.

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