Piperazin-2-one amides as inhibitors of factor xa

Details Piperazin-2-one amides as inhibitors of factor xa Piperazin-2-one amides as inhibitors of factor xa

C - Chemistry, Metallurgy

07

D

C07D 409/12 (2006.01) A61K 31/495 (2006.01) A61P 7/02 (2006.01) C07D 221/00 (2006.01) C07D 241/08 (2006.01) C07D 317/00 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01)

Patent

CA 2422873

Novel piperazin-2-one containing compounds of general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivative having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.

L'invention concerne de nouveaux composants contenant du pipérazine-2-un de formules générales (I) ou (II) : comprenant leur isomères, leurs sels, leurs hydrates, leurs solvats et leurs dérivés de promédicaments pharmaceutiquement acceptables possédant une activité contre le facteur Xa mammifère. L'invention concerne également les compositions contenant ces composants. Ces composants et ces compositions servent <i>in vitro</i> ou <i>in vivo</i> à empêcher ou traiter des conditions chez des mammifères caractérisées par une thrombose non-souhaitée.

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