Piperazine derivatives

Details Piperazine derivatives Piperazine derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/246

C07D 295/15 (2006.01) A61K 31/395 (2006.01) C07D 205/04 (2006.01) C07D 221/20 (2006.01) C07D 239/42 (2006.01) C07D 295/084 (2006.01) C07D 295/088 (2006.01) C07D 295/125 (2006.01) C07D 295/13 (2006.01) C07D 295/145 (2006.01) C07D 295/185 (2006.01) C07D 319/20 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2015034

Piperazine derivatives of formula Image and their pharmaceutically acceptable acid addition salts are disclosed. Tn the formula n is 1 or 2, R is hydrogen or lower alkyl, R1 is an aryl or nitrogen containing heteroaryl radical, R2 is hydrogen or lower alkyl, R3 is aryl, C4-8 alkyl or aryl(lower)alkyl and X is a functionalised group of specified meaning. The compounds exhibit activity as 5-HT1A antagonists and can be used, into alia, for the treatment of CNS disorders, such as anxiety.

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