Piperazine derivatives and their use as therapeutic agents

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/42 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61P 3/06 (2006.01) C07D 241/26 (2006.01)

Patent

CA 2533901

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

L'invention concerne des méthodes de traitement d'une maladie ou d'un état pathologique médiés par SCD chez un mammifère, de préférence un humain, lesdites méthodes consistant à administrer à un mammifère en ayant besoin un composé représenté par la formule (I) dans laquelle G, J, L, M, x, y, W, V, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?8a¿, R?9¿, R?9a¿, R?10¿, R?10a¿, R?11 ¿et R?11a¿ sont tels que définis. L'invention concerne également des compositions pharmaceutiques contenant les composés représentés par la formule (I).

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