C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/12 (2006.01) A61K 31/495 (2006.01) A61K 38/06 (2006.01) C07D 241/08 (2006.01) C07D 471/04 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2289621
Compounds of formula (A) are disclosed wherein R1 is aralkyl or cycloalkyl; R2 is cycloalkylmethyl, alkyl, or aralkyl; R3 is hydrogen, alkyl, substituted phenyl (including p-phenoxy-phenyl), or fluorene; R4 is hydrogen, alkyl, substituted phenyls (including 1-alkyl-4-carboxy-substituted phenyls), alkyl carboxylic acids; R5 is hydrogen or R1 and R5 taken together forming a tetrahydroisoquinoline ring or a piperidine ring. These compounds exhibit inhibitory action against fructose-1,6-bisphosphatase (FBPase) and are indicating in the treatment or management of Type II diabetes.
L'invention concerne des composés correspondant à la formule A dans laquelle R?1¿ est aralalkyle ou cycloalkyle; R?2¿ est cycloalkylméthyle, alkyle ou aralkyle; R?3¿ est hydrogène, alkyle, phényle substitué (y compris p-phénoxy-phényle) ou fluorène; R?4¿ est hydrogène, alkyle, phényles substitués (y compris phényles 1-alkyl-4-carboxy substitués), acides d'alkyle carboxylique; R?5¿ est hydrogène ou R?1¿ et R?5¿ pris conjointement et formant un cycle de tétrahydroisoquinonline ou de pipéridine. Ces composés manifestent une action d'inhibition vis-à-vis de fructose-1,6-bisphosphatase (FBPase) et sont recommandés pour le traitement ou la prise en charge du diabète type 1.
Arienti Kristen Lee
Jones Todd Kevin
Kimmich Rachel Denise Anne
Mason James Christopher
Mjalli Adnan M. M.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ontogen Corporation
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