Piperidine and azetidine derivatives as glyt1 inhibitors

Details Piperidine and azetidine derivatives as glyt1 inhibitors Piperidine and azetidine derivatives as glyt1 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4178 (2006.01) A61K 31/4439 (2006.01) A61K 31/4545 (2006.01) A61P 25/18 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2592345

The present invention provides compounds of formula (I), wherein both p's are one or two, R1 is generally heteroaryl or cycloalkyl, R2 is C3-6cycloalkyl or phenyl and R3 is heteroaryl, and pharmaceutically acceptable salts thereof, as GlyT1 inhibitors for treating schizophrenia, pharmaceutical compositions comprising the same and methods for their preparation.

La présente invention concerne des composés de formule (I), ou les deux p sont égaux à un ou à deux, R1 représente généralement un hétéroaryle ou un cycloalkyle, R2 représente un cycloalkyle en C3-C6 ou un phényle et R3 représente un groupement hétéroaryle, ainsi que des sels de qualité pharmaceutique de ces composés, en tant qu'inhibiteurs de GlyT1. Lesdits composés et leurs sels entrent dans le traitement de la schizophrénie. La présente invention concerne également des préparations pharmaceutiques comprenant lesdits composés et leurs sels, ainsi que des méthodes de synthèse desdits composés et de leurs sels.

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