C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/454 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2533749
The present invention provides methods for the use of compounds as depicted by structure (I), pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCID inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
La présente invention concerne des méthodes d'utilisation de composés tels que représentés par la structure (I), des compositions pharmaceutiques les contenant et des méthodes de prophylaxie, de gestion et de traitement de maladies métaboliques et de maladies modulées par l'inhibition de la malonyl-CoA décarboxylase (MCD). Les composés selon la présente invention sont utiles pour la prophylaxie, la gestion et le traitement de maladies intervenant dans la voie du métabolisme du glucose/des acides gras régulée par la malonyl-CoA. Lesdits composés et ladite composition pharmaceutique les contenant sont notamment indiqués dans la prophylaxie, la gestion et le traitement de maladies cardiovasculaires, du diabète, du cancer et de l'obésité.
Arrhenius Thomas
Chen Mi
Cheng Jie Fei
Dyck Jason R.
Lopaschuk Gary D.
Chugai Seiyaku Kabushiki Kaisha
Torys Llp
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