C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/26 (2006.01) A61K 31/445 (2006.01) A61K 31/4523 (2006.01) A61P 9/14 (2006.01) A61P 11/00 (2006.01) A61P 19/02 (2006.01) C07C 275/26 (2006.01) C07C 275/28 (2006.01) C07D 209/08 (2006.01) C07D 211/58 (2006.01) C07D 211/96 (2006.01) C07D 213/40 (2006.01) C07D 295/20 (2006.01) C07D 401/06 (2006.01) C07D 487/18 (2006.01)
Patent
CA 2646154
Compounds of the formula (I); wherein R1 is a member selected from the group consisting of C1-C8alkyl, arylC0-C8alkyl, C3-C12cycloalkyl and heterocyclyl, Y1 is selected from the group consisting of a bond, C(R5)2, NR5 and O; Y2 is selected from the group consisting of a bond, NR5 and O; each R2, R3 and R5 is independently selected from the group consisting of H, alkyl and COR6; A is heterocyclyl, optionally substituted with from 1 to 2 R7 substituents; L is selected from the group consisting of a direct bond, C1-C12alkylene, C1-C12heteroalkylene, C3-C6cycloalkylene, arylene, heteroarylene, -CO-, -SOin- and -Se-; R4 is selected from the group consisting of H, C1C8alkyl, C2-C6alkenyl, C2-C6alkynyl, C1,-C8heteroalkyl, arylC0-C8alkyl, C3C,12cycloalkyl and heterocyclyl, are claimed. The compounds are inhibitors of the soluble epoxide hydrolase (sEH) and useful for the treatment of hypertension, inflammation, adult respiratory distress syndrome; diabetic complications; end stage renal disease; Raynaud syndrome and arthritis.
La présente invention concerne des inhibiteurs d'époxyde hydrolase soluble (sEH) qui comprennent plusieurs pharmacophores et qui sont utiles dans le traitement de maladies.
Gless Richard Jr.
Hammock Bruce D.
Huang Huazhang
Jones Paul D.
Morisseau Christophe
Arete Therapeutics
Fetherstonhaugh & Co.
The Regents Of The University Of California
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