Piperidinyl, indolyl, pirinidyl, morpholinyl and...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/26 (2006.01) A61K 31/445 (2006.01) A61K 31/4523 (2006.01) A61P 9/14 (2006.01) A61P 11/00 (2006.01) A61P 19/02 (2006.01) C07C 275/26 (2006.01) C07C 275/28 (2006.01) C07D 209/08 (2006.01) C07D 211/58 (2006.01) C07D 211/96 (2006.01) C07D 213/40 (2006.01) C07D 295/20 (2006.01) C07D 401/06 (2006.01) C07D 487/18 (2006.01)

Patent

CA 2646154

Compounds of the formula (I); wherein R1 is a member selected from the group consisting of C1-C8alkyl, arylC0-C8alkyl, C3-C12cycloalkyl and heterocyclyl, Y1 is selected from the group consisting of a bond, C(R5)2, NR5 and O; Y2 is selected from the group consisting of a bond, NR5 and O; each R2, R3 and R5 is independently selected from the group consisting of H, alkyl and COR6; A is heterocyclyl, optionally substituted with from 1 to 2 R7 substituents; L is selected from the group consisting of a direct bond, C1-C12alkylene, C1-C12heteroalkylene, C3-C6cycloalkylene, arylene, heteroarylene, -CO-, -SOin- and -Se-; R4 is selected from the group consisting of H, C1C8alkyl, C2-C6alkenyl, C2-C6alkynyl, C1,-C8heteroalkyl, arylC0-C8alkyl, C3C,12cycloalkyl and heterocyclyl, are claimed. The compounds are inhibitors of the soluble epoxide hydrolase (sEH) and useful for the treatment of hypertension, inflammation, adult respiratory distress syndrome; diabetic complications; end stage renal disease; Raynaud syndrome and arthritis.

La présente invention concerne des inhibiteurs d'époxyde hydrolase soluble (sEH) qui comprennent plusieurs pharmacophores et qui sont utiles dans le traitement de maladies.

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