Plasmodium falciparum virulence factor var o

Details Plasmodium falciparum virulence factor var o Plasmodium falciparum virulence factor var o

C - Chemistry, Metallurgy

12

N

C12N 15/30 (2006.01) A61K 31/7088 (2006.01) A61K 39/015 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/445 (2006.01) C07K 16/20 (2006.01) C12N 5/06 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2446662

The present invention relates to the discovery of the var O gene specific to the Palo Alto FUP/SP-O strain of Plasmodium falciparum and the corresponding protein, an adhesin that mediates rosetting and auto-agglutination of red blood cells in malaria pathogenesis. Novel biological tools and methods of use of the foregoing are disclosed including nucleic acid molecules, polypeptides, antibodies, recombinant vectors, recombinant host cells, and corresponding diagnostic and therapeutic applications of the foregoing.

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