C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 39/015 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07K 14/445 (2006.01) C07K 16/20 (2006.01) C07K 17/00 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2037151
Abstract Polypeptides which coincide in at least one specific epitope with a Plasmodium falciparum sporozoite antigen with the N-terminal amino-acid sequence shown in Fig. 1, and a process for the preparation thereof, are disclosed. The invention furthermore relates to immuno- genic compositions which contain a polypeptide of this type and a suitable adjuvant, to a DNA which codes for a polypeptide of this type, to replicable microbial vectors which contain a DNA of this type, to microorganisms which contain a replicable vector of this type, and to anti- bodies against a polypeptide according to the invention. Processes for the preparation of the immunogenic composi- tions, of the microorganisms and of the antibodies, and the use of the polypeptides and of the immunogenic compositions for the immunisation of mammals against malaria are claimed.
Certa Ulrich
Guttinger Maria
Matile Hugues
Certa Ulrich
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
Guttinger Maria
Hoffman-La Roche(f.) Co. Aktiengesellschaft
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