Plaster for the transdermal administration of volatile,...

Details Plaster for the transdermal administration of volatile,... Plaster for the transdermal administration of volatile,...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/135 (2006.01) A61L 15/16 (2006.01)

Patent

CA 2146645

The invention relates to a patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature which comprises a multi-element system comprising (a) a matrix having distributed therein as the drug said volatile active ingredient or a physiologically acceptable salt thereof, the matrix comprising a pressure-sensitive adhesive, (b) an element of a pressure-sensitive adhesive composition which - where (a) contains a salt - contains basic groups to liberate the free base from its salt, (c) a backing layer impermeable to the diffusable ingredients of (a) and (b), and (d) a release liner impermeable to the diffusable ingredients of (a) and (b), matrix (a) or at least a part of (b), whichever is in contact with release liner (d), having a tack sufficient for affixing the patch to the skin, any part of (b) positioned between matrix (a) and release liner (d) being permeable for the active ingredient, preferably deprenyl, or the salt thereof or both. The invention also relates to a process for preparing such patch.

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