Poly(peptide) as a chelator: methods of manufacture and uses

Details Poly(peptide) as a chelator: methods of manufacture and uses Poly(peptide) as a chelator: methods of manufacture and uses

A - Human Necessities

61

K

A61K 51/08 (2006.01)

Patent

CA 2603437

Novel compositions for imaging that include (a) a polypeptide that includes two or more consecutive amino acids that will function to non-covalently bind valent metal ions and (2) a valent metal ion chelated to at least one of the two consecutive amino acids, are disclosed. Also disclosed are methods of imaging using these novel compositions, such as methods of imaging a tumor within a subject. Methods of synthesizing an imaging agent and kits for preparing an imaging agent are also disclosed. Methods for determining the effectiveness of a candidate substance as an imaging agent that involve conjugating or chelating the candidate substance with a polypeptide that includes two or more consecutive amino acids that will function to non- covalently bind valent metal ions.

La présente invention concerne de nouvelles compositions destinées à l'imagerie qui incluent (a) un polypeptide qui inclut deux ou plusieurs acides aminés consécutif qui auront pour effet de lier de façon non covalente des ions métalliques valents et (2) un ion métallique valent chélaté sur l'un au moins des deux acides aminés consécutifs. L'invention concerne également des procédés d'imagerie utilisant ces nouvelles compositions, et notamment de procédés d'imagerie de tumeur chez un sujet. L'invention concerne aussi des procédés de synthèse d'un agent d'imagerie et des nécessaires pour élaborer un agent d'imagerie. L'invention concerne enfin des procédés d'évaluation de l'efficacité de candidates substances comme agent d'imagerie avec conjugaison ou chélation de la candidate substance avec un polypeptide incluant plusieurs acides aminés consécutifs ayant pour effet de lier de façon non covalente des ions métalliques valents.

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