Polyarylcarbamoylaza - and - carbamoylalkanedioic acids

Details Polyarylcarbamoylaza - and - carbamoylalkanedioic acids Polyarylcarbamoylaza - and - carbamoylalkanedioic acids

C - Chemistry, Metallurgy

07

D

C07D 211/08 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) C07C 233/22 (2006.01) C07C 235/74 (2006.01) C07D 211/42 (2006.01) C07D 211/70 (2006.01) C07D 213/56 (2006.01) C07D 215/14 (2006.01) C07D 241/04 (2006.01) C07D 263/56 (2006.01) C07D 263/57 (2006.01) C07D 277/66 (2006.01) C07D 291/08 (2006.01) C07D 401/02 (2006.01) C07D 401/10 (2006.01) C07D 405/10 (2006.01) C07D 413/02 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 417/02 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2207429

This invention relates to a class of novel dicarboxy amide derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis-aryl and/or heteroaryl alkyl or cycloalkylamino dicarboxy amides. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

La présente invention concerne une classe de nouveaux dérivés dicarboxy amides d'amines lipophiles présentant des propriétés inhibitrices de la squalène synthase. Plus spécifiquement, ces composés sont des dicarboxy amides bis-aryl et/ou hétéroaryl alkyl ou cycloalkylamino. Lesdits composés réduisent les taux de cholestérol sérique dans l'organisme sans réduire de façon sensible la synthèse des métabolites mévaloniques. L'invention concerne aussi des compositions pharmacologiques et des méthodes de traitement pour abaisser les taux de cholestérol sérique à l'aide desdits composés.

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