Polycyclic sugar surrogate-containing oligomeric compounds...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/04 (2006.01) A61K 48/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2504694

Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a polycyclic sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a polycyclic sugar surrogate modification.

Compositions oligomères comprenant un premier et un second oligomère dans lesquelles au moins une partie du premier oligomère peut s'hybrider avec au moins une partie du second oligomère, au moins une partie du premier oligomère est complémentaire d'un acide nucléique cible avec lequel elle peut s'hybrider, et au moins une partie du premier ou du second oligomère présente une modification comprenant un substitut de sucre polycyclique. L'invention concerne également des compositions oligomère/protéine complémentaires d'un acide nucléique sélectionné avec lequel elles peuvent s'hybrider et au moins une protéine contenant au moins une partie d'un complexe de silençage induit par ARN, un au moins des nucléosides de l'oligomère présente une modification d'un substitut de sucre polycyclique.

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