Polymer compound for biomedical use and biochip substrate...

C - Chemistry – Metallurgy – 08 – K

Patent

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C08K 5/20 (2006.01)

Patent

CA 2601432

There is provided a biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acid and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate , and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.

L'invention concerne un substrat de biopuce destiné à réaliser une précision de détection élevée par restriction d'une adsorption non spécifique ou par liaison d'un substrat à détecter, lorsqu'il est utilisé dans la détection ou l'analyse de protéines, d'acide nucléique et analogue. Un substrat de biopuce sert à fixer une substance active sur le plan biologique sur une surface d'un substrat solide, et est caractérisé en ce qu'elle comporte une couche contenant un composé polymère obtenir par copolymérisation d'un monomère polymérisable non saturé sur le plan éthylénique possédant des restes d'alkylène glycol, d'un monomère polymérisable non saturé sur le plan éthylénique possédant un groupe fonctionnel destiné à fixer une substance active sur le plan biologique et un monomère polymérisable non saturé sur le plan éthylénique possédant un groupe fonctionnel réticulé chimiquement, sur la surface du substrat.

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