Polymer conjugates of box-a of hmgb1 and box-a variants of...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61M 25/00 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01)

Patent

CA 2663300

The present invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A. Further, the invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A). Moreover, the present invention concerns the use of said polymer conjugates of polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and/or associated with an increased expression of RAGE.

L'invention concerne de nouveaux conjugués polymères de variantes polypeptidiques de la boîte A du domaine de liaison ayant une forte affinité avec HGMB1 (Boîte A de HMGB1) ou un fragment actif biologiquement de la Boîte A de HMGB1. L'invention concerne également de nouveaux conjugués polymères de variantes polypeptidiques de la boîte A du domaine de liaison ayant une forte affinité avec HGMB1 (Boîte A de HMGB1). L'invention concerne également l'utilisation desdits conjugués polymères de molécules polypeptidiques de Boîte A de HMGB1 pour diagnostiquer, prévenir, atténuer et/ou traiter des pathologies associées à la protéine HGMB1 extracellulaire et/ou à une expression accrue de RAGE.

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