Polymers for delivering nitric oxide in vivo

Details Polymers for delivering nitric oxide in vivo Polymers for delivering nitric oxide in vivo

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 47/48 (2006.01) C08B 37/16 (2006.01) C08F 8/30 (2006.01)

Patent

CA 2262922

Disclosed are novel polymers derivatized with at least one -NO x group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.

On décrit des nouveaux polymères modifiés et présentant au moins un groupe -NOX par unité de masse atomique 1200 du polymère, X valant un ou deux. Dans un mode de réalisation, ce polymère est un polymère S-nitrosé et on le prépare en faisant réagir un polymère à plusieurs groupes thiol avec un agent de nitrosation dans des conditions appropriées à une nitrosation des groupes thiol libres. On peut utiliser les polymères de la présente invention pour enrober des dispositifs médicaux, afin d'apporter du monoxyde d'azote in vivo au niveau des sites de traitement.

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