C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/5377 (2006.01)
Patent
CA 2748853
A polymorphic form of rivaroxaban, 5-chloro-N-{[(5S)-2-oxo-3-[4-(3- oxomorpholin-4-yl)phenyl]oxa-zolidin-5- yl]- methyl}thiophene-2-carboxamide (termed form APO-A), processes for the preparation thereof, and compositions and formulations comprising form APO-A are provided. Also provided are compositions comprising a crystalline form of rivaroxaban and solvents selected from C3 to C6 ketones, C3 to C4 amides and mixtures thereof.
L'invention concerne une forme polymorphe du rivaroxaban, la 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phényl]oxa-zolidin-S-yl]méthyl}thiophène-2-carboxamide (appelée forme APO-A), ses procédés de préparation et des compositions et formulations comportant la forme APO-A. L'invention concerne également des compositions comportant une forme cristalline du rivaroxaban et des solvants choisis parmi les cétones en C3 à C6, les amides en C3 à C4 et les mélanges de ces composés.
Bodhuri Prabhudas
Weeratunga Gamini
Apotex Pharmachem Inc.
Mckinnon Graham J.k.
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