Polymorphic forms of a 3-pyrrole substituted 2-indolinone

Details Polymorphic forms of a 3-pyrrole substituted 2-indolinone Polymorphic forms of a 3-pyrrole substituted 2-indolinone

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/405 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2709083

The invention relates to new crystalline polymorphic forms of N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-l,2-dihydro-2-oxo-3H-indol-3- ylidine)methyl]-2,4- dimethyl-1H-pyrrole-3-carboxamide (i.e., sunitinib base), including Form I, Form II, and Form IV, processes for preparing crystalline polymorphic forms of sunitinib base, and pharmaceutically acceptable salts of new crystalline polymorphic forms of sunitinib base and pharmaceutical compositions comprising new crystalline polymorphic forms of sunitinib base, salts of new crystalline polymorphic forms of sunitinib base and mixtures thereof.

L'invention porte sur de nouvelles formes polymorphes cristallines de N-[2-(diéthylamino)éthyl]-5-[(Z)-(5-fluoro-l,2-dihydro-2-oxo-3H-indol-3-ylidine)méthyl]-2,4-diméthyl-1H-pyrrole-3-carboxamide (à savoir, le sunitinib base) comprenant la forme I, la forme II et la forme IV, sur des procédés permettant de préparer des formes polymorphes cristallines du sunitinib base et sur des sels pharmaceutiquement acceptables de nouvelles formes polymorphes cristallines du sunitinib base et sur des compositions pharmaceutiques comprenant de nouvelles formes polymorphes cristallines du sunitinib base, des sels de nouvelles formes polymorphes cristallines de sunitinib base et leurs mélanges.

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