A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/06 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 31/77 (2006.01) A61K 39/12 (2006.01) A61K 47/34 (2006.01) A61K 48/00 (2006.01) A61M 31/00 (2006.01) A61K 9/107 (2006.01)
Patent
CA 2359886
The present invention relates to compositions of polynucleotides, such as viruses, RNA, DNA, or derivatives thereof comprising polynucleotides and block copolymers of alkylethers. The invention also relates to methods of treating animals comprising intramuscular and intradermal administration of the compositions of the invention. The invention also provides methods of delivering polynucleotides to a cell comprising administering to the cell the compositions comprising polynucleotides and block copolymers. The invention also provides compositions and methods for stabilizing polynucleic acids and increasing the ability of polynucleic acids to cross cell membranes and act in the interior of a cell.
L'invention concerne des compositions à base de polynucléotides (par exemple, virus, ARN, ADN ou dérivés correspondants), qui comprennent des polynucléotides et des copolymères séquencés d'alkyléther. L'invention concerne également des procédés relatifs au traitement d'animaux, par administration intramusculaire et intradermique des compositions considérées. L'invention concerne en outre des procédés consistant à administrer des polynucléotides à une cellule par administration à la cellule des compositions qui renferment les polynucléotides et les copolymères séquencés en question. L'invention concerne enfin des compositions et des procédés permettant de stabiliser des acides polynucléiques et d'augmenter la capacité des acides polynucléiques à traverser les membranes de cellules et à agir à l'intérieur des cellules.
Alakhov Valery Y.
Kabanov Alexander V.
Lemieux Pierre M.
Vinogradov Sergey V.
Borden Ladner Gervais Llp
Supratek Pharma Inc.
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