Polynucleotides allowing the expression and secretion of...

Details Polynucleotides allowing the expression and secretion of... Polynucleotides allowing the expression and secretion of...

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A61K 39/245 (2006.01) C07K 14/02 (2006.01)

Patent

CA 2699465

This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells.

L'invention concerne une nouvelle approche de la conception d'un virus présentant un cycle de réplication défectueux, qui peut être sauvé par co-infection par un virus de type sauvage et qui exprime des épitopes antigéniques étrangers contribuant à l'élimination des cellules infectées par le virus puis à la clairance virale. Le vecteur selon l'invention permet, par l'expression d'épitopes issus d'agents pathogènes communs, de contourner la tolérance existante de réactions de lymphocytes T spécifiques d'un virus. Ce vecteur ne se réplique que dans des cellules infectées par un virus.

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