C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 38/46 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/16 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2432041
The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
L'invention concerne de nouveaux polynucléotides codant pour des polypeptides phosphatase humains, des fragments et des homologues de ces derniers. L'invention concerne également des vecteurs, des cellules hôtes, des anticorps et des procédés de recombinaison et de synthèse pour produire ces polypeptides. L'invention concerne en outre des méthodes diagnostiques et thérapeutiques pour appliquer ces nouveaux polypeptides phosphatase humains au diagnostic, au traitement et/ou à la prévention de diverses maladies et/ou de divers troubles associés à ces polypeptides, notamment des maladies et/ou troubles cardiovasculaires. L'invention concerne enfin des procédés de criblage destinés à identifier des agonistes et des antagonistes des polynucléotides et des polypeptides de la présente invention.
Banas Dana
Bassolino Donna
Bol David
Feder John
Finger Joshua
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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