C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/03 (2006.01) A61K 31/195 (2006.01) A61K 38/04 (2006.01) C07C 237/12 (2006.01) C07C 237/20 (2006.01) C07C 237/22 (2006.01) C07C 271/22 (2006.01) C07D 207/16 (2006.01) C12N 1/20 (2006.01) C12P 13/04 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2289981
A compound of formula (I) wherein R1 represents amino which may be substituted; R2 represents carboxy which may be esterified or amidated; R3, R4, R5, and R6 each represents hydroxy which may be protected; Q represents aryl which may be substituted; or a salt thereof. The compound (I) possesses anti-Helicobacter pylori activity, and useful in the prevention or treatment of various diseases associated with Helicobacter bacteria, such as duodenal ulcer, gastric ulcer, chronic gastritis, and cancer of the stomach.
L'invention porte sur un composé de formule (I) dans laquelle R?1¿ représente amino facultativement substitué; R?2¿ représente carboxy facultativement estérifié ou amidé; R?3¿, R?4¿, R?5¿ et R?6¿ représentent chacun hydroxy facultativement protégé; Q représente aryle facultativement substitué; ou l'un de leurs sels. Le composé (I) agit sur l'helicobacter pylori et s'avère utile pour prévenir ou traiter différentes maladies associées à la bactérie helicobacter telles que l'ulcère duodénal, l'ulcère gastrique, les gastrites chroniques, et le cancer de l'estomac.
Akiyama Yohko
Izawa Motoo
Kamiyama Keiji
Miyagawa Ken-Ichiro
Nakano Yoshitaka
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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