C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2377618
The invention relates to the use of constrained coiled-coil polypeptides to mimic .alpha.-helical structural elements of native proteins. These constrained peptidyl mimetics are used to generate and/or identify ligands which selectively bind the .alpha.-helical segment contained in the native protein.
L'invention concerne l'utilisation de polypeptides bispiralés contraints permettant d'imiter des éléments de structure .alpha.-hélicoïdale de protéines natives. Ces mimétiques peptidyles contraints servent à produire et/ou identifier des ligands qui se lient sélectivement au segment .alpha.-hélicoïdal contenu dans la protéine native.
Hodges Robert S.
Irvin Randall T.
Kondejewski Leslie H.
Gowling Lafleur Henderson Llp
Hodges Robert S.
Irvin Randall T.
Kondejewski Leslie H.
The Governors Of The University Of Alberta
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