Polypeptide compound and a process for preparation thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/56 (2006.01) A61K 38/12 (2006.01) C07K 1/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2123921

ABSTRACT The invention relates to novel polypeptide compounds having the general formula: Image [ I ] wherein R1 is a hydrogen atom, R2 is an acyl group, R3 is a hydroxy or acyloxy group, R4 is a hydroxy or hydroxysulfonyloxy group, R5 is a hydrogen atom or a lower alkyl group which is optionally substituted with a hydroxy, acyl, di(lower)alkylamino or cyclic amino group, and R6 is a hydrogen atom, a hydroxy or acyl (lower) alkylthio group, and pharmaceutically acceptable salts thereof. The polypeptide compounds of formula [I] and their pharmaceutically acceptable salts are useful for the prophylactic and/or therapeutic treatment of infectious diseases caused by pathogenic microorganisms.

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