Polypeptide inhibitors of gamma interferon

Details Polypeptide inhibitors of gamma interferon Polypeptide inhibitors of gamma interferon

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/21 (2006.01) A61K 38/45 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2070416

2070416 9105799 PCTABS00005 Novel synthetic polypeptides comprising the amino acid subsequence Arg-Arg-Lys-Trp-Gln are provided by this invention. Also provided are methods for the use of such polypeptides, other known polypeptides containing such subsequence and a variety of acidic or basic polypeptides and proteins as inhibitors of the binding of gamma interferon to its cellular receptors. The methods of this invnetion are potentially applicable to the treatment of pathological conditions believed to be mediated by gamma interferon, such as autoimmune disease.

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