Polypeptide nucleic sequences exported from mycobacteria,...

Details Polypeptide nucleic sequences exported from mycobacteria,... Polypeptide nucleic sequences exported from mycobacteria,...

C - Chemistry, Metallurgy

12

N

C12N 15/74 (2006.01) A61K 39/04 (2006.01) A61K 48/00 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2301374

The invention concerns recombinant vectors replicated in mycobacteria, a set of sequences coding for exported polypeptides detected by fusion with alkaline phosphatase, in particular a polypeptide, called DP428, of about 12 kD corresponding to an exported protein found in mycobacteria belonging to the Mycobacterium tuberculosis complex. The invention also concerns methods and kits for detecting in vitro the presence of a mycobacterium and in particular a mycobacterium belonging to the Mycobacterium tuberculosis complex in a biological sample using said polypeptides, their fragments or polynucleotides coding for the latter. The invention further concerns immunogenic compositions or vaccines for preventing and/or treating infections caused by mycobacteria and in particular a mycobacterium belonging to said complex, particularly tuberculosis.

L'invention a pour objet des vecteurs recombinants se réplicant chez les mycobactéries, un ensemble de séquences codant pour des polypeptides exportés détectés par des fusions avec la phosphatase alcaline, notamment un polypeptide, dénommé DP428, d'environ 12kD correspondant à une protéine exportée retrouvée dans les mycobactéries appartenant au complexe de Mycobacterium tuberculosis. L'invention concerne également des procédés et des kits de détection in vitro de la présence d'une mycobactérie et en particulier une mycobactérie appartenant au complexe de Mycobacterium tuberculosis dans un échantillon biologique utilisant lesdits polypeptides, leurs fragments ou des polynucléotides codant pour ces derniers. L'invention vise des compositions immunogènes ou vaccins pour la prévention et/ou le traitement d'infections provoquées par des mycobactéries et en particulier une mycobactérie appartenant audit complexe, en particulier la tuberculose.

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