C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2683791
The invention relates to anti-VEGF pol ypeptides and antibody single variable domains (dAbs) that are resi stant to degradation by a prot ease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.
L'invention concerne des polypeptides anti-VEGF et des domaines uniques variables (dAbs) d'anticorps qui résistent à une dégradation par une protéase, ainsi que des antagonistes comprenant ces derniers. Les polypeptides, les dAbs et les antagonistes sont utilisés pour être administrés par voie pulmonaire ou orale, et distribués aux poumons et au tractus grastro-intestinal d'un patient, ainsi que pour traiter le cancer ou une maladie inflammatoire, telle que l'arthrite.
Batuwangala Thil Dinuk
Enever Carolyn
Jespers Laurent
Pupecka Malgorzata
Steward Michael
Domantis Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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